P-46: Effect of Formaldehyde Toxicity on The Gonadotropin Hormones and Epithelial Cells of Testicular Tubules in Male Rat

Background: Formaldehyde is a chemical that used in fixed tissues and bodies. Formaldehyde during dissection of cadaver, evaporate and be released. Studies have shown that the gas increase endogenous opioids, nitric oxide and cytokines in plasma. These impacts can affect on gonadotropin hormones. The aim of this study was to investigate possible changes in gonadotropin and epithelial cells of testicular tubules in male rat by formaldehyde exposed. Materials and Methods: In this study, 24 adult rats were randomly divided into three groups: 1. control, 2. experimental group: formaldehyde exposure 2 hours per day, 3. in the experimental group formaldehyde exposed 4 hours per day. 18 weeks after the test, serum concentrations of FSH, LH and testosterone by Radioimmunoassay, and changes of epithelial cells of testicular tubules was studied. Results: The results indicated that a decrease in FSH and testosterone in experimental groups compared to the control group. Levels of LH plasma in experimental groups compared to the other groups decreased significantly (p<0.05) shows the evaluation of tissue sections for different groups showed that tubule of seminiferous and interstitial tissue that appears normal, epithelial cells of The tubules were uniformly distributed without gaps and without any cell loss. Conclusion: Formaldehyde vapor decreased gonadotropin but has no effect on testicular seminiferous epithelial cells. It is conjectured that the seminiferous epithelial cells of adult rat testis to gonadotropin hormones is not only dependent on many other factors may be involved.